Hydrochlorothiazide: The commonest indicators and signs and symptoms of overdose observed in people are All those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from abnormal diuresis.

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For the reason that irbesartan would not inhibit ACE, it does not affect the reaction to bradykinin; irrespective of whether this has scientific relevance is just not known.

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Patients encountering an overdose could present with hypokalemia, hypochloremia, and hyponatremia. Treat individuals with symptomatic and supportive therapy such as fluids and electrolytes. Vasopressors might be administered to treat hypotension and oxygen could arena plus possibly be supplied for respiratory impairment.

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Irbesartan: No knowledge can be found in regard to overdosage in individuals. On the other hand, day-to-day doses of 900 mg for eight months ended up perfectly tolerated. The most likely manifestations of overdosage are expected for being hypotension and tachycardia; bradycardia may additionally occur from overdose. Irbesartan isn't taken out by hemodialysis.To get up-to-day information regarding the cure of overdosage, a very good useful resource can be a Accredited regional Poison Regulate Centre. Phone figures of Accredited Poison Management Facilities are outlined while in the Doctors’ Desk Reference (PDR).

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